Endocrine Abstracts

Background: Atypical carcinoid tumours are rare which account for about 15% of all carcinoid tumours. Some of those tumours secrete adrenocorticotrophic hormone (ACTH) causing Cushing's syndrome. We present a case which recurred 16 years after being first diagnosed.Case: A 39 years old woman was referred with few months history of weight gain, irregular menstrual periods, muscle aches, difficult going up the stairs, headaches and blurred vision.She was i...

Background: Atypical antipsychotic agents are useful in treating patients with schizophrenia and other psychoses, but may cause hyperglycaemia. Hyperglycaemia is not dose dependent and is reversible on stopping the treatment.Occurrence of diabetes after atypical antipsychotic drug administration is of major concern as patients may not recognise their symptoms, and health workers may fail to reach an early diagnosis, with major implications for morbidity ...

Introduction: NICE recommends that pregnant women with pre-existing diabetes should be offered retinal assessment in the 1st and 3rd trimester by digital retinal imaging. Where retinopathy is already present, an additional assessment should be made in the 2nd trimester.Objectives: To assess the feasibility of retinal screening in pregnancy by a community based mobile retinal screening programme (MRSP).Methods: A retrospective audit...

Background: Metabolic surgery has been hailed as a potential new treatment (‘magic bullet’) for obese patients with type2 diabetes. Several studies have shown that metabolic surgery for morbid obese patients with type2 diabetes can lead to considerable weight loss and also has positive impact on the incidence of type2 diabetes, in some cases leading to elimination of the disease in up to 80% of patients. But metabolic surgery do not seem to induce similar ‘magic...

AimsTo present the case of a 69 year-old female patient who was diagnosed with acromegaly two years following the initial onset of facial and acral symptoms, having already developed colonic hyperplastic polyps, one of the complications associated with acromegaly, one year prior to diagnosis.MaterialCase report and literature review.MethodAcromegaly was diagnosed ...

Background: Second generation antipsychotics (SGAs) are increasingly playing a bigger role in the treatment of schizophrenia and other psychiatric conditions due to their lower extra pyramidal side effect profile However, SGAs are known to cause clinically relevant metabolic derangements including hyperglycaemiaCase: A 70-year-old gentleman was admitted with generalised weakness and increased urinary frequency (polyuria) and polydipsia. His blood glucose...

Introduction: Doxycycline is a broad-spectrum antibiotic that is used to treat gram negative, gram positive and atypical bacterial infections. It is a member of the second-generation tetracycline class of antibiotics.Case: We describe a case of a (non-diabetic) male patient who developed hypoglycaemia following treatment with doxycycline. A 73-year-old male presented to the emergency department following a witnessed collapse at 9am on the 4tho...

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 has led to unparalleled burden on national and global healthcare systems. Vaccines were viewed as way of combating Covid 19 pandemic. This led to development and implementation of vaccination programmes worldwide. Several vaccines have been approved for use in worldwide including Pfizer-BioNTech, Oxford-AstraZeneca vaccine and Moderna vaccine. Disturbingly, the speed at which these va...

Introduction: Development and progression of cancers is multifactorial encompassing several mechanisms that aid its proliferation. One of the hallmarks of cancer progression is inhibition of the immune system. Cancer cells can activate different immune checkpoint are pathways that harbour inhibitory or stimulatory mechanisms that enabled self-tolerance and assist with immune response. Through activation of immune checkpoint pathways cancers can suppress immune response against...

Background: Thyrotoxicosis is one of the commonest endocrine disorders and its severe form can manifest as thyroid storm in acute setting leading to organ dysfunctions including heart failure. Cases: 1: A 58-year-old female with a significant past medical history of MI, paroxysmal AF/atrial flutter, and hyperthyroidism presented with a one-week history of palpitations, plethora, diaphoresis, heat intolerance, loose stools, and a TSH <0.01; Free T4-33...